« All Photo Galleries ‘Grey’s Anatomy’ Top 10 Couples

2. Derek and Meredith

Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are MerDer and there’s almost nothing else to say. The epic one night stand that kickstarted started the entire show of Grey’s Anatomy and turned into a full on epic romance. They survived secret wives, one near-drowning, shootings, one plane crash and a bazillion innovation brain surgeries. May all you MerDer fans enjoy watching seasons 1 through 10 and pretend season 11 never happened.

Grey's Anatomy/ABC

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