DJ EZ Rock, best known for collaborating with longtime friend Rob Base on “It Takes Two,” died on Saturday. He was 46.

DJ EZ Rock Dies

EZ Rock’s death was confirmed by Base, reported TMZ. His cause of death has not yet been revealed.

Born Rodney Bryce, the Harlem-native teamed up with Base in 1988 for “It Takes Two,” which went on to be a Top 40 hit and has been named by Rolling Stone as one of the 50 Greatest Hip-Hop Songs of All Time. Since it debuted in the 80s, “It Takes Two” has been sampled by a number of artists, including Snoop Dog. It’s also made its way onto a number of soundtracks – most recently 2009’s The Proposal, which starred Sandra Bullock and Ryan Reynolds.

EZ Rock and Base also worked together on “DJ Interview” and “Joy and Pain,” which was also a chart hit.

Many in the hip-hop community have taken to Twitter to share their condolences in regard to EZ Rock’s passing, including rapper Biz Markie, DJ Red Alert and DJ Scratch.

R.I.P. TO EZ ROCK FROM ROB BASE AND EZ ROCK YOU WILL TRULY BE MISSED. .

— BIZ MARKIE (@BizMarkie) April 27, 2014

We Have Lost Our Very Own From Harlem NYC & The Hip-Hop Culture Our Brother DJ E-Z Rock. Rest In Peace… https://t.co/qyEhZhzcnH

— DJ Red Alert (@KoolDJRedAlert) April 27, 2014

Rest In Peace DJ EZ Rock. https://t.co/EtovEBlBNX

— Turntable Whisperer (@DJScratch) April 27, 2014

– Chelsea Regan