Actress Susan Tyrrell wasn't your typical Oscar-nominee. The unconventional screen star, who gained a cult following for her Academy Award-nominated portrayal of a barfly in John Huston's 1973 film, Fat City, as well as her role opposite Johnny Depp in John Waters' 1990 musical, Cry-Baby, died in her sleep on Sunday in her Austin, Texas home at the age of 67.

Tyrrell was diagnosed with thrombocythemia, a rare disease of the bone marrow, in 2000, reports Entertainment Weekly. She had to have both her legs amputated at the time, though she later continued to act, appearing in Masked and Anonymous in 2003 and this year's Kid-Thing.

"The last thing my mother said to me was, 'SuSu, your life is a celebration of everything that is cheap and tawdry," Tyrrell once told writer Paul Cullum. "I've always liked that, and I've always tried to live up to it."