Jessica Chastain stars, with Jess Weixler, in the indy film The Disappearance of Eleanor Rigby, written and directed by Ned Benson. The film is comprised of three parts showing different perspectives on the troubled marriage of Eleanor (Chastain) and Conor (James McAvoy) — Him, Her and Them, which is set for release Oct. 10.

Although the movie delves into weighty topics, Chastain and Weixler, who play sisters in the film but are actually best friends off-screen, found time to have some fun. “I was laughing all the way up to the point where I actually threw out my back in the fight scene, cause we were in it – we were in the thick of it,” Weixler told uInterview.

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Q: Where are your characters at the beginning of the movie? - Uinterview

JESSICA CHASTAIN: Eleanor at the beginning of the film, she goes through flashbacks. So, when we first meet Eleanor, it’s in the beginning of love; so she’s drunk in love and there’s something kind of selfish about it, they run out on a bill. It's like they have eyes only for each other and this beautiful moment that they’re in. It becomes difficult for her because a tragedy strikes them and she has to then navigate her way through life in a kind of very adult way. So there’s two ways that we meet Eleanor in the beginning.

JESS WEIXLER: In the beginning I think Katie comes to pick her up, can I say from the hospital?

JC: No. Um, yeah. Spoiler.

JW: Just a slight spoiler, so I come to pick her up and so I think I am walking on eggshells trying to take care of her and not say the wrong thing and not do the wrong thing around her, 'cause I really just wanna take care of my sister. But as it progresses, as in sister relationships, I start to needing to be taken care of also.

Q: Do you think that women view relationships differently than men? - Uinterview

JC: Well, I think it depends definitely on the man and the woman. I do, I know, that sometimes I’ve had different views of the relationship based on the men I’ve been with. So, yes, it can be. Ned definitely believes that way. When he wrote the films, it’s the male perspective and the female perspective, so much is different. Even things about the relationships in the film, like in what’s opening on Oct. 10, with the Him/Her version, like in her we deal with mother-daughter relationships, sisters relationships, daughter-father, you know friendships and that to me is just as important as the love component of the film.

JW: I would say also, any two people probably take something different from a moment - male or female. Any two people in a room will walk away and have different memories of what happened.

Q: It’s a serious movie, what’s the lightest moment you had on set? - Uinterview

JC: Oh yeah.

JW: Oh yeah!

JC: We have a little bit of a fight scene on film, and we kept laughing before that cause we’re like we get to punch each other!

JW: I was laughing all the way up to the point where I actually threw out my back in the fight scene, 'cause we were in it - we were in the thick of it!

JC: Yeah, we were pulling hair, all of that stuff. We’ve known each other, we went to college together, were best friends, we’re like sisters so it was really fun to be like, we’re going to fight!